Rickels K, Weise C, Case G, Hucker H
Psychopharmacology (Berl). 1983;80(1):14-8. doi: 10.1007/BF00427486.
Seventy-four patients were treated with 150 mg/day amitriptyline (AT) to determine possible correlations between clinical improvement, demographic variables, and AT and nortriptyline (NT) plasma levels. Plasma level determinations after 2 and 6 weeks of treatment revealed that moderately significant correlations existed between AT plasma levels and clinical improvement, dosage intake, age, weight, sex, and coffee intake. Some of these findings were more pronounced after 2, and some after 6 weeks of treatment.
74名患者接受了每日150毫克阿米替林（AT）的治疗，以确定临床改善、人口统计学变量以及AT和去甲替林（NT）血浆水平之间可能存在的相关性。治疗2周和6周后的血浆水平测定显示，AT血浆水平与临床改善、剂量摄入、年龄、体重、性别和咖啡摄入量之间存在中度显著相关性。其中一些发现在治疗2周后更为明显，而另一些则在治疗6周后更为明显。
