Babor T F, Berglas S, Mendelson J H, Ellingboe J, Miller K
Psychopharmacology (Berl). 1983;80(1):53-60. doi: 10.1007/BF00427496.
A study was conducted to investigate the effects of acute alcohol administration on affective states and verbal behavior during the ascending and descending limbs of the blood alcohol curve. Sixteen male social drinkers were given alcohol (1.0 g/kg) or placebo in a double-blind crossover research design. Subjects tested while blood alcohol levels (BAL) were ascending close to peak concentration (0.11 g%) described themselves as more elated, friendly, and vigorous than when tested under placebo conditions. As BAL declined, subjects described themselves as more angry, depressed, and fatigued. Cognitive confusion, hostile verbal interaction, and aggressive thematic content were also greater during alcohol intoxication, but these measures were unrelated to direction of change in the BAL curve. It was concluded that (1) the effects of alcohol on affect are biphasic and are closely related to direction of change in the BAL curve, (2) the disinhibition of certain types of verbal behavior is related neither to affective state or to direction of the BAL curve, and (3) the perception of cognitive disorientation may mediate the effects of alcohol on those behaviors normally suppressed by various controlling influences.
一项研究旨在调查急性酒精摄入对血酒精浓度曲线上升和下降阶段情感状态及言语行为的影响。在双盲交叉研究设计中,16名男性社交饮酒者被给予酒精(1.0克/千克)或安慰剂。在血酒精水平(BAL)上升接近峰值浓度(0.11克%)时接受测试的受试者表示,与在安慰剂条件下接受测试相比,他们感觉更加兴高采烈、友好且精力充沛。随着BAL下降,受试者表示自己更加愤怒、沮丧和疲惫。在酒精中毒期间,认知混乱、敌意言语互动和攻击性主题内容也更为明显,但这些指标与BAL曲线的变化方向无关。研究得出结论:(1)酒精对情感的影响是双相的,且与BAL曲线的变化方向密切相关;(2)某些类型言语行为的去抑制既与情感状态无关,也与BAL曲线的方向无关;(3)认知定向障碍的感知可能介导酒精对那些通常受各种控制影响而被抑制的行为的作用。