猫中麦角酸二乙胺（LSD）和麦角酰二乙胺（lisuride）行为效应的拮抗作用。
Antagonism of a behavioral effect of LSD and lisuride in the cat.
作者信息
White F J, Holohean A M, Appel J B
出版信息
Psychopharmacology (Berl). 1983;80(1):83-4. doi: 10.1007/BF00427501.
These experiments investigated the role of serotonin 5-HT) and dopamine (DA) receptors in the limb-flick (LF) response elicited by the hallucinogenic ergot LSD and its nonhallucinogenic structural congener lisuride. Pretreatment with either the 5-HT antagonist pizotifen (BC-105) or the DA antagonist haloperidol significantly attenuated LF elicited by either LSD or lisuride. Thus, the LF model failed to differentiate the neuropharmacological actions of LSD and lisuride. Cocaine also prevented LSD- and lisuride-elicited LF simply by reducing the activity of cats (response competition) suggesting the need for caution in interpreting 'antagonism' of the LF response.
这些实验研究了5-羟色胺（5-HT）和多巴胺（DA）受体在致幻麦角酸二乙酰胺（LSD）及其非致幻结构类似物麦角酰二乙胺引发的甩尾（LF）反应中的作用。用5-HT拮抗剂苯噻啶（BC-105）或DA拮抗剂氟哌啶醇预处理可显著减弱LSD或麦角酰二乙胺引发的LF。因此，LF模型未能区分LSD和麦角酰二乙胺的神经药理学作用。可卡因也只是通过降低猫的活动（反应竞争）来阻止LSD和麦角酰二乙胺引发的LF，这表明在解释LF反应的“拮抗作用”时需要谨慎。
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