Adams L M, Geyer M A
Pharmacol Biochem Behav. 1985 Sep;23(3):461-8. doi: 10.1016/0091-3057(85)90022-x.
In order to further validate a previously proposed animal model of the effects of LSD in humans, doses of 5, 15, 30 and 60 micrograms/kg lisuride (a non-hallucinogenic congener of LSD) were studied using a behavioral pattern monitor (BPM). The BPM provided both quantitative measures of crossovers, rearings, and holepokes and qualitative measures of spatial patterns of locomotion. A holeboard chamber connected to a homecage provided two test situations. Rats were tested either with (free exploration) or without access to the homecage (forced exploration). In both situations, lisuride exhibited a biphasic dose-response curve for horizontal locomotion (low dose suppression and high dose enhancement), while rearing was significantly reduced at all doses. Lisuride also produced a dose-dependent increase in the perseverative quality of locomotor patterns. A comparison of these results with our previous studies with lysergic acid diethalmide (LSD) indicate that, with the exception of rearings, lisuride fails to mimic LSD's characteristic effects on exploratory activity. Rather, lisuride exhibited many similarities to the dopamine angonist apomorphine.
为了进一步验证先前提出的关于麦角酰二乙胺（LSD）对人类影响的动物模型，使用行为模式监测仪（BPM）研究了5、15、30和60微克/千克的麦角酰乙胺（LSD的一种非致幻同类物）剂量。BPM提供了交叉、竖毛和探洞的定量测量以及运动空间模式的定性测量。连接到饲养笼的洞板箱提供了两种测试情况。大鼠在有（自由探索）或没有进入饲养笼（强制探索）的情况下接受测试。在两种情况下，麦角酰乙胺对水平运动均呈现双相剂量反应曲线（低剂量抑制和高剂量增强），而在所有剂量下竖毛均显著减少。麦角酰乙胺还使运动模式的持续性质量呈剂量依赖性增加。将这些结果与我们先前使用麦角酸二乙酰胺（LSD）的研究进行比较表明，除了竖毛外，麦角酰乙胺未能模拟LSD对探索活动的特征性影响。相反，麦角酰乙胺与多巴胺激动剂阿扑吗啡表现出许多相似之处。
