Shitakha V M, Natulya V M, Musoke A J, Ramasamy R, Buscher G
Vet Immunol Immunopathol. 1983 Apr;4(3):361-73. doi: 10.1016/0165-2427(83)90046-6.
The role played by complement and fibrinolysis in the pathogenesis of pulmonary oedema and the disseminated, subendothelial, petechial haemorrhages in cattle infected with Theileria parva was investigated. There was a marked reduction in total haemolytic complement in animals that died of this disease whereas the survivors showed only transient changes. The reduction in C3 levels in animals with severe disease, however, was equivalent to that in the survivors. Neither circulating soluble immune complexes nor free antibody against macroschizonts were detected in sera from cattle with severe infection. In addition to the complement changes, high levels of fibrinogen degradation products (FDPs) were detected in sera from the infected animals. The rate of production of FDPs and reduction in total haemolytic complement paralleled the clinical course of the disease. It is, therefore, suggested that the pulmonary oedema and disseminated petechial haemorrhages seen in East Coast fever may be the direct result of the combined effects of complement activation and consumption of fibrinogen and fibrin.
研究了补体和纤维蛋白溶解在感染小泰勒虫的牛肺水肿及弥漫性、内皮下瘀点性出血发病机制中的作用。死于该病的动物总溶血补体显著降低，而存活动物仅表现出短暂变化。然而，重症动物的C3水平降低程度与存活动物相当。在重症感染牛的血清中未检测到循环可溶性免疫复合物或抗大裂殖体的游离抗体。除补体变化外，在感染动物的血清中检测到高水平的纤维蛋白原降解产物（FDPs）。FDPs的产生速率和总溶血补体的降低与疾病的临床病程平行。因此，有人提出，东海岸热中出现的肺水肿和弥漫性瘀点性出血可能是补体激活以及纤维蛋白原和纤维蛋白消耗共同作用的直接结果。
