Amato D, Khan N R
Acta Haematol. 1983;70(1):1-10. doi: 10.1159/000206682.
We have studied the growth of erythroid bursts in methylcellulose cultures from bone marrow (7 cases) and peripheral blood cells (17 cases) of patients with primary acquired refractory anemias. In most cases, erythroid burst-forming units (BFU-E) were either absent or present in lower than normal numbers, and these levels remained low to absent in sequential studies. In 2 patients, circulating BFU-E were initially higher than normal, but subsequently declined to normal levels. 1 patient had low-normal numbers of circulating BFU-E initially, but these declined to zero in a later study. No clinical or routine hematological features permitted distinction between patients with initially high BFU-E and those with initially low or absent BFU-E. These findings parallel those reported for granulocyte-macrophage progenitors in refractory anemias, and support the concept that erythroid progenitor cells in these disorders are influenced by the disordered hematopoiesis.
我们研究了原发性获得性难治性贫血患者骨髓（7例）和外周血细胞（17例）在甲基纤维素培养基中红系爆式集落的生长情况。在大多数病例中，红系爆式集落形成单位（BFU-E）要么缺失，要么数量低于正常，并且在后续研究中这些水平仍维持在低水平或缺失状态。在2例患者中，循环中的BFU-E最初高于正常，但随后降至正常水平。1例患者最初循环中的BFU-E数量略低于正常，但在后来的研究中这些数量降至零。没有临床或常规血液学特征能够区分最初BFU-E高的患者和最初BFU-E低或缺失的患者。这些发现与难治性贫血中粒细胞-巨噬细胞祖细胞的报道结果相似，并支持了这些疾病中的红系祖细胞受造血紊乱影响的概念。
