锌在大鼠分娩中作用的研究。
Studies on the role of zinc in parturition in the rat.
作者信息
Bunce G E, Wilson G R, Mills C F, Klopper A
出版信息
Biochem J. 1983 Mar 15;210(3):761-7. doi: 10.1042/bj2100761.
Abstract
- Pregnant rats were fed either low (less than 1 p.p.m.) Zn or control (40 p.p.m. Zn) diets from day 10 of gestation. They were killed at intervals during the last 96 h preceding the normal time for onset of parturition, and differences in plasma progesterone, oestradiol-17 beta and ovarian 20 alpha-hydroxysteroid dehydrogenase were assessed. 2. Gestation was prolonged in Zn-deficient rats. 3. Although the preparturient decline in plasma progesterone began at the same time in all groups, at term, plasma progesterone concentration in Zn-deficient rats remained significantly higher than in normal females. 4. Induction of ovarian 20 alpha-hydroxysteroid dehydrogenase activity was delayed by about 8 h by Zn deficiency. This delay was not observed if prostaglandin F2 alpha was injected previously. 5. The results suggest a Zn-dependent step(s) in uterine synthesis and/or release of prostanoids.
摘要
- 从妊娠第10天起，给怀孕大鼠喂食低锌（低于1 ppm）或对照（40 ppm锌）日粮。在正常分娩时间前的最后96小时内，每隔一段时间将它们处死，并评估血浆孕酮、雌二醇-17β和卵巢20α-羟基类固醇脱氢酶的差异。2. 缺锌大鼠的妊娠期延长。3. 尽管所有组血浆孕酮在产前的下降都在同一时间开始，但足月时，缺锌大鼠的血浆孕酮浓度仍显著高于正常雌性大鼠。4. 缺锌使卵巢20α-羟基类固醇脱氢酶活性的诱导延迟约8小时。如果预先注射前列腺素F2α，则未观察到这种延迟。5. 结果表明，子宫合成和/或释放前列腺素的过程中有一个锌依赖步骤。
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