葡萄糖对糖尿病大鼠肝细胞中磷酸化酶和糖原合酶的影响。
Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats.
作者信息
Bollen M, Hue L, Stalmans W
出版信息
Biochem J. 1983 Mar 15;210(3):783-7. doi: 10.1042/bj2100783.
Abstract
The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phosphorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.
摘要
研究了葡萄糖对从急性（40小时）和慢性（90小时）四氧嘧啶糖尿病大鼠分离的肝细胞中磷酸化酶和糖原合酶的影响。在所有条件下，葡萄糖诱导的磷酸化酶失活均正常进行。随后糖原合酶的激活在急性糖尿病中略有减弱，但在严重程度相似的72小时糖尿病中几乎消失。在患有不同程度慢性糖尿病的大鼠的肝细胞中，糖原合酶的最大激活（在60 mM葡萄糖时）与血糖浓度呈负相关。
相似文献
1
Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats.葡萄糖对糖尿病大鼠肝细胞中磷酸化酶和糖原合酶的影响。
Biochem J. 1983 Mar 15;210(3):783-7. doi: 10.1042/bj2100783.
2
Control of glycogen synthase and phosphorylase in hepatocytes from diabetic rats. Effects of glucagon, vasopressin, and vanadate.糖尿病大鼠肝细胞中糖原合酶和磷酸化酶的调控。胰高血糖素、血管加压素和钒酸盐的作用。
Diabetes. 1989 Jun;38(6):793-8. doi: 10.2337/diab.38.6.793.
3
Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes.在肝细胞中，葡萄糖必须被磷酸化以激活糖原合酶，但不是为了使糖原磷酸化酶失活。
FEBS Lett. 1992 Jan 20;296(2):211-4. doi: 10.1016/0014-5793(92)80381-p.
4
Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes.葡萄糖和咖啡因对分离肝细胞中糖原磷酸化酶a和合成酶b去磷酸化作用的调节
Can J Biochem. 1981 Jun;59(6):387-95. doi: 10.1139/o81-054.
5
Regulation of rat liver glycogen synthase. Roles of Ca2+, phosphorylase kinase, and phosphorylase a.大鼠肝脏糖原合酶的调节。钙离子、磷酸化酶激酶和磷酸化酶a的作用。
J Biol Chem. 1983 May 10;258(9):5490-7.
6
Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats.胰高血糖素样肽1对正常和糖尿病大鼠肝细胞中糖原合酶a动力学的影响。
Endocrinology. 1998 Jun;139(6):2811-7. doi: 10.1210/endo.139.6.6045.
7
Synthesis of glycogen from fructose in the presence of elevated levels of glycogen phosphorylase a in rat hepatocytes.在大鼠肝细胞中，在糖原磷酸化酶a水平升高的情况下由果糖合成糖原。
Mol Cell Biochem. 1980 Mar 20;30(1):33-8. doi: 10.1007/BF00215303.
8
The hepatic defect in glycogen synthesis in chronic diabetes involves the G-component of synthase phosphatase.慢性糖尿病中糖原合成的肝脏缺陷涉及合酶磷酸酶的G组分。
Biochem J. 1984 Jan 15;217(2):427-34. doi: 10.1042/bj2170427.
9
Insulin regulation of hepatic glycogen synthase and phosphorylase.胰岛素对肝糖原合酶和磷酸化酶的调节。
Biochemistry. 1978 Feb 7;17(3):406-10. doi: 10.1021/bi00596a004.
10
Use of adult rat cardiomyocytes to study cardiac glycogen metabolism.利用成年大鼠心肌细胞研究心脏糖原代谢。
Am J Physiol. 1987 May;252(5 Pt 1):E673-8. doi: 10.1152/ajpendo.1987.252.5.E673.
引用本文的文献
1
Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism.紫檀水提取物对组织糖原含量及碳水化合物代谢关键酶的影响。
Mol Cell Biochem. 2002 Dec;241(1-2):53-9. doi: 10.1023/a:1020870526014.
2
Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase.肝脏中葡萄糖诱导的糖原生成涉及糖原合酶的6-磷酸葡萄糖依赖性去磷酸化。
Biochem J. 1997 Mar 15;322 ( Pt 3)(Pt 3):745-50. doi: 10.1042/bj3220745.
3
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.糖原化合物5-碘杀结核菌素作为一种通用蛋白激酶抑制剂的鉴定。
Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):123-8. doi: 10.1042/bj2990123.
4
Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes.C-1-取代葡萄糖类似物对大鼠肝细胞中糖原合酶和糖原磷酸化酶激活状态的影响。
Biochem J. 1995 Nov 1;311 ( Pt 3)(Pt 3):845-52. doi: 10.1042/bj3110845.
5
The hepatic defect in glycogen synthesis in chronic diabetes involves the G-component of synthase phosphatase.慢性糖尿病中糖原合成的肝脏缺陷涉及合酶磷酸酶的G组分。
Biochem J. 1984 Jan 15;217(2):427-34. doi: 10.1042/bj2170427.
6
The activity of glycogen synthase phosphatase limits hepatic glycogen deposition in the adrenalectomized starved rat.糖原合酶磷酸酶的活性限制了肾上腺切除饥饿大鼠肝脏中的糖原沉积。
Biochem J. 1983 Aug 15;214(2):539-45. doi: 10.1042/bj2140539.
7
Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat hepatocytes.谷氨酰胺对分离的大鼠肝细胞中糖原合成和脂肪生成的刺激作用。
Biochem J. 1987 Dec 1;248(2):429-37. doi: 10.1042/bj2480429.
8
Differences in liver glycogen-synthase phosphatase activity in rodents with spontaneous insulin-dependent and non-insulin-dependent diabetes.自发性胰岛素依赖型和非胰岛素依赖型糖尿病啮齿动物肝脏糖原合酶磷酸酶活性的差异。
Diabetologia. 1988 Sep;31(9):711-3. doi: 10.1007/BF00278757.
9
Oral administration of vanadate to streptozotocin-diabetic rats restores the glucose-induced activation of liver glycogen synthase.给链脲佐菌素诱导的糖尿病大鼠口服钒酸盐可恢复葡萄糖诱导的肝糖原合酶激活。
Biochem J. 1990 Apr 1;267(1):269-71. doi: 10.1042/bj2670269.
10
Fasting enhances glycogen synthase activation in hepatocytes from insulin-resistant genetically obese (fa/fa) rats.禁食可增强胰岛素抵抗型遗传性肥胖（fa/fa）大鼠肝细胞中糖原合酶的活性。
Biochem J. 1990 Aug 1;269(3):789-94. doi: 10.1042/bj2690789.
本文引用的文献
1
Isolation and characterization of liver glycogen synthase from diabetic rats.糖尿病大鼠肝脏糖原合酶的分离与鉴定
Arch Biochem Biophys. 1982 Feb;213(2):492-503. doi: 10.1016/0003-9861(82)90575-6.
2
Alteration of hepatic glycogen synthase phosphatase activity by insulin deficiency.胰岛素缺乏对肝糖原合酶磷酸酶活性的影响。
Am J Physiol. 1981 May;240(5):E539-43. doi: 10.1152/ajpendo.1981.240.5.E539.
3
Glycogen-synthase phosphatase activity in rat liver. Two protein components and their requirement for the activation of different types of substrate.大鼠肝脏中的糖原合酶磷酸酶活性。两种蛋白质成分及其对不同类型底物激活的需求。
Eur J Biochem. 1980 Feb;104(1):137-46. doi: 10.1111/j.1432-1033.1980.tb04409.x.
4
Synthesis of liver glycogen in starved alloxan diabetic rats.饥饿的四氧嘧啶糖尿病大鼠肝脏糖原的合成
Diabetes. 1970 Dec;19(12):916-23. doi: 10.2337/diab.19.12.916.
5
The effect of diabetes and insulin on liver glycogen synthetase activation.糖尿病和胰岛素对肝糖原合成酶激活的影响。
J Biol Chem. 1970 Feb 25;245(4):903-5.
6
Insulin and the regulation of hepatic biosynthetic activity.胰岛素与肝脏生物合成活性的调节
Vitam Horm. 1966;24:1-61. doi: 10.1016/s0083-6729(08)60202-2.
7
Dependence on insulin of the apparent hydrocortisone activation of hepatic glycogen synthetase.肝糖原合成酶的表观氢化可的松激活对胰岛素的依赖性。
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1515-9. doi: 10.1073/pnas.58.4.1515.
8
The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose.给小鼠和大鼠注射葡萄糖后，肝脏中糖原磷酸化酶的顺序失活和糖原合成酶的激活。肝脏对葡萄糖的阈值机制。
Eur J Biochem. 1974 Jan 3;41(1):127-34. doi: 10.1111/j.1432-1033.1974.tb03252.x.
9
Mechanism of control of hepatic glycogenesis by insulin.胰岛素对肝糖原生成的调控机制。
J Biol Chem. 1973 May 25;248(10):3483-8.
10
The relationship between insulin and apparent glucocorticoid-promoted activation of hepatic glycogen synthetase.胰岛素与糖皮质激素促进肝糖原合成酶激活之间的关系。
Biochim Biophys Acta. 1972 Sep 15;279(2):245-59. doi: 10.1016/0304-4165(72)90140-7.
Zotero 插件