Rosenberg R S, Duffy P H, Sacher G A, Ehret C F
Bioelectromagnetics. 1983;4(2):181-91. doi: 10.1002/bem.2250040208.
White-footed mice, Peromyscus leucopus, were exposed to 60-Hz electric fields to study the relationship between field strength and three measures of the transient arousal response previously reported to occur with exposures at 100 kV/m. Five groups of 12 mice each were given a series of four 1-h exposures, separated by an hour, with each group exposed at one of the following field strengths: 75, 50, 35, 25, and 10 kV/m; 8 additional mice were sham-exposed with no voltage applied to the field generator. All mice were experimentally naive before the start of the experiment, and all exposures occurred during the inactive (lights-on) phase of the circadian cycle. The first exposure produced immediate increases in arousal measures, but subsequent exposures had no significant effect on any measure. These arousal responses were defined by significant increases of gross motor activity, carbon dioxide production, and oxygen consumption, and were frequently recorded with field strengths of 50 kV/m or higher. Significant arousal responses rarely occurred with exposures at lower field strengths. Responses of mice exposed at 75 and 50 kV/m were similar to previously described transient arousal responses in mice exposed to 100-kV/m electric fields. Less than half of the mice in each of the field strength groups below 50 kV/m showed arousal responses based on Z (standard) scores, but the arousals of the mice that did respond were similar to those of mice exposed at higher field strengths. Polynomial regression was used to calculate the field strength producing the greatest increases for each of the arousal measures. The results show that the amplitude of the transient arousal response is related to the strength of the electric field, but different measures of arousal may have different relationships to field strength.
将白足鼠（Peromyscus leucopus）暴露于60赫兹的电场中，以研究场强与先前报道的在100 kV/m暴露下发生的瞬态觉醒反应的三种测量指标之间的关系。将五组每组12只小鼠进行一系列四次1小时的暴露，每次暴露间隔1小时，每组分别暴露于以下场强之一：75、50、35、25和10 kV/m；另外8只小鼠进行假暴露，不对场发生器施加电压。在实验开始前，所有小鼠均未经过实验处理，所有暴露均发生在昼夜节律周期的非活动（开灯）阶段。第一次暴露使觉醒测量指标立即增加，但随后的暴露对任何测量指标均无显著影响。这些觉醒反应的定义是总体运动活动、二氧化碳产生和氧气消耗显著增加，并且经常在50 kV/m或更高的场强下记录到。在较低场强下暴露时，很少发生显著的觉醒反应。暴露于75和50 kV/m的小鼠的反应与先前描述的暴露于100 kV/m电场的小鼠的瞬态觉醒反应相似。在50 kV/m以下的每个场强组中，不到一半的小鼠基于Z（标准）分数显示觉醒反应，但有反应的小鼠的觉醒情况与暴露于较高场强的小鼠相似。使用多项式回归来计算每种觉醒测量指标产生最大增加的场强。结果表明，瞬态觉醒反应的幅度与电场强度有关，但不同的觉醒测量指标与场强可能有不同的关系。
