Marazzini L, Gatti L, Cavestri R, Longhini E
J Appl Physiol Respir Environ Exerc Physiol. 1978 Apr;44(4):538-41. doi: 10.1152/jappl.1978.44.4.538.
To determine the relative importance of control system and of mechanical and metabolic properties of the motor system on the maximal frequency of breathing (1/t) at various tidal volumes (VT), we have studied the relationship between cycle period (t) and tidal volume in 10 normal subjects, in 9 patients with chronic obstructive lung disease, and in a normal subject breathing against different resistive loads. The results, expressed according to the equation t = t0 + b VT (where t0 represents the time required for a breathing cycle at zero VT and b means the additional time required for a breathing cycle with a VT equal to vital capacity), indicate that t0 is independent from the load either in unloaded or loaded normal subjects or in obstructive patients. In fact, although b was found significantly different, t0 remained essentially constant. These findings suggest that the level of maximal voluntary ventilation may be mainly related to metabolic and mechanical properties of the motor system (muscles of breathing and load imposed on them).
为了确定控制系统以及运动系统的机械和代谢特性对不同潮气量（VT）下呼吸最大频率（1/t）的相对重要性，我们研究了10名正常受试者、9名慢性阻塞性肺疾病患者以及1名在不同阻力负荷下呼吸的正常受试者的周期时长（t）与潮气量之间的关系。根据方程t = t0 + bVT（其中t0表示潮气量为零时呼吸周期所需的时间，b表示潮气量等于肺活量时呼吸周期所需的额外时间）得出的结果表明，在无负荷或有负荷的正常受试者以及阻塞性患者中，t0与负荷无关。实际上，尽管发现b有显著差异，但t0基本保持不变。这些发现表明，最大自主通气水平可能主要与运动系统（呼吸肌及其所承受的负荷）的代谢和机械特性有关。
