Scano G, van Meerhaeghe A, Willeput R, Vachaudez J P, Sergysels R
Eur J Respir Dis. 1982 Jan;63(1):23-30.
In 10 exercising patients with chronic obstructive lung disease (COLD) we measured ventilation (VE), end-tidal CO2 (PETCO2), mean inspiratory flow (VT/TI), the ratio of inspiratory time to total time for one cycle (TI/TTOT), and occlusion pressure at 0.1 s measured at the mouth (P O.1), when they breathed room air and 100% oxygen. Oxygen breathing increased the maximal work load achieved. Furthermore, at the same exercise load, P O.1, VT/TI, VE, heart rate, respiratory frequency (f) decreased significantly in hyperoxia as compared with normoxia. Thoraco-pulmonary impedance assessed by P 0.1/VE and P 0.1/(VT/TI) ratios showed a slight but significant decrease to the respiratory centre. Thus in exercising patients affected by COLD, hyperoxia not only decreases the chemical afferent drive but also may slightly reduce the afferent mechanical drive to the respiratory centre. The decrease in the thoraco-pulmonary impedance may be explained either by an increase in efficiency of the respiratory muscles and/or a decrease in airway resistance.
在10例患有慢性阻塞性肺疾病（COLD）的运动患者中，我们测量了他们呼吸室内空气和100%氧气时的通气量（VE）、呼气末二氧化碳分压（PETCO2）、平均吸气流量（VT/TI）、吸气时间与一个周期总时间的比值（TI/TTOT）以及口腔测量的0.1秒时的阻断压（P0.1）。吸氧增加了达到的最大工作负荷。此外，在相同运动负荷下，与常氧相比，高氧时P0.1、VT/TI、VE、心率、呼吸频率（f）显著降低。通过P0.1/VE和P0.1/（VT/TI）比值评估的胸肺阻抗显示对呼吸中枢有轻微但显著的降低。因此，在患有COLD的运动患者中，高氧不仅降低化学传入驱动，而且可能略微降低对呼吸中枢的传入机械驱动。胸肺阻抗的降低可能是由于呼吸肌效率提高和/或气道阻力降低所致。
