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[通过定量测定5-羟色胺细胞器的荧光强度研究血小板功能]

[Study of platelet function by quantitative determination of the fluorescence intensity of 5HT-organelles].

作者信息

Astrina O S, Lomazova Kh D, Pokrovskiĭ V I

出版信息

Biull Eksp Biol Med. 1983 Jul;96(7):29-31.

PMID:6409182
Abstract

Assay of the fluorescence intensity of 5HT-organelles was performed to examine the functional properties of platelets from patients with meningococcal infection. Platelets were found to have a higher capacity for endocytosis at the height of the disease, tending to its normalization with treatment and convalescence. Incubation of donor's plasma rich in platelets with meningococcal lipopolysaccharide was discovered to lead to an appreciable increase in the absorption capacity of platelets. It is suggested that endotoxinemia is one of the factors responsible for the impairment of platelet function.

摘要

检测5-羟色胺细胞器的荧光强度,以检查脑膜炎球菌感染患者血小板的功能特性。发现血小板在疾病高峰期具有更高的内吞能力,随着治疗和康复趋于正常化。发现富含血小板的供体血浆与脑膜炎球菌脂多糖一起孵育会导致血小板吸收能力明显增加。提示内毒素血症是导致血小板功能受损的因素之一。

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