硝苯地平在高血压治疗中的作用。
Role of nifedipine in treatment of hypertension.
作者信息
Murphy M B, Scriven A J, Dollery C T
出版信息
Br Med J (Clin Res Ed). 1983 Jul 23;287(6387):257-9. doi: 10.1136/bmj.287.6387.257.
Abstract
The efficacy of nifedipine in the treatment of hypertension was assessed in 15 patients whose hypertension continued while being treated with atenolol 100 mg and bendrofluazide 5 mg daily. Nifedipine was added in doses of 10, 20, and 30 mg three times daily in a placebo controlled, double blind trial. One patient was withdrawn from the trial because of severe postural hypotension with the highest dose. Erect and supine blood pressure in the remaining 14 patients were significantly reduced by all doses of nifedipine. The drug was well tolerated but plasma potassium fell by 0.3 mmol(mEq)/1 during treatment (p less than 0.05). Nifedipine is thus effective in the treatment of hypertension but should probably be used in combination with a potassium sparing diuretic.
摘要
在15例高血压患者中评估了硝苯地平的疗效，这些患者在每日服用100mg阿替洛尔和5mg苄氟噻嗪治疗期间仍持续存在高血压。在一项安慰剂对照、双盲试验中，每日三次分别给予10mg、20mg和30mg剂量的硝苯地平。一名患者因使用最高剂量时出现严重体位性低血压而退出试验。其余14例患者的立位和卧位血压在所有剂量的硝苯地平治疗下均显著降低。该药物耐受性良好，但治疗期间血浆钾下降了0.3mmol（mEq）/L（p<0.05）。因此，硝苯地平在治疗高血压方面有效，但可能应与保钾利尿剂联合使用。
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