Rabaud M, Lefebvre F, Desgranges C, Bricaud H
C R Seances Acad Sci III. 1983;296(7):345-50.
The present paper deals with the particular behavior of the complexes formed between pancreatic elastase and seric inhibitors in the Pig, when they were set in contact with homologous elastin. The previously known values of dissociation constants of alpha 1-antiprotease-elastase and alpha 2-macroglobulin-elastase complexes indicated they were very stable and almost irreversible. Nevertheless, our results suggest that, when the overall complexes between porcine pancreatic elastase and seric inhibitors were isolated in non drastic conditions, they might develop an elastolytic activity against elastin fibers. This result is important as regards atherosclerosis--in Human--where a destruction of elastin is involved at a early stage of the disease.
本文探讨了猪胰弹性蛋白酶与血清抑制剂形成的复合物在与同源弹性蛋白接触时的特殊行为。先前已知的α1-抗蛋白酶-弹性蛋白酶和α2-巨球蛋白-弹性蛋白酶复合物的解离常数表明它们非常稳定且几乎不可逆。然而，我们的结果表明，当在非剧烈条件下分离猪胰弹性蛋白酶与血清抑制剂之间的整体复合物时，它们可能对弹性蛋白纤维产生弹性溶解活性。就人类动脉粥样硬化而言，这一结果很重要，因为在该疾病的早期阶段涉及弹性蛋白的破坏。
