Hladká A, Takácová T, Líska D
Czech Med. 1983;6(1):8-14.
A statistically significant dependence of the levels of polychlorinated biphenyls (PCB's) in the blood of white rats on the quantity of repeated doses of Delor was found. The effect of PCB content in the blood of animals on the changes of selected biochemical functions was studied in a short-term experiment. When PCB concentrations were proximate to the proposed biological limit (200 micrograms PCB. 1(-1) of blood), the content of cholesterol, triglycerides and total lipides in serum increased statistically significantly which indicates an intervention of PCB's into the metabolism of lipides. Depending on the doses of Delor administered, the relative weight of the animals' livers increased statistically significantly. Even at low levels of PCB's im blood hepatotoxic effects of Delor were manifested by statistically significant changes in the activities of sorbitol and malate dehydrogenases. Activity changes of the given serum dehydrogenases were proportional to the quantity of the dose of Delor administered.
发现白鼠血液中多氯联苯（PCB）的含量与重复剂量的狄氏剂之间存在统计学上的显著相关性。在一项短期实验中，研究了动物血液中PCB含量对所选生化功能变化的影响。当PCB浓度接近建议的生物限值（每升血液200微克PCB）时，血清中胆固醇、甘油三酯和总脂质的含量在统计学上显著增加，这表明PCB对脂质代谢有干预作用。根据所给予的狄氏剂剂量，动物肝脏的相对重量在统计学上显著增加。即使血液中PCB含量较低，狄氏剂的肝毒性作用也表现为山梨醇和苹果酸脱氢酶活性的统计学显著变化。给定血清脱氢酶的活性变化与所给予的狄氏剂剂量成正比。
