Brussaard J H, Katan M B, Hautvast J G
Eur J Clin Invest. 1983 Apr;13(2):115-22. doi: 10.1111/j.1365-2362.1983.tb00075.x.
The effect of different amounts and types of dietary fat on faecal steroid excretion in healthy volunteers was examined. In the first experiment with sixty volunteers four diets which differed in type and amount of dietary fat only were compared during a test-period of 5 weeks. Faeces were collected during 7 days before and at the end of the test period and analysed individually. In the second experiment with thirty-five volunteers, a low fat diet containing 22% of energy as total fat (4% as polyunsaturated fatty acids) was compared with a moderate fat diet (30% of energy as total fat; 11% as polyunsaturated fatty acids) during 13 weeks. Faeces were collected during the first 7 days of the test period and during 7 consecutive days near the end of the test period and pooled per dietary group. Excretion of faecal neutral steroids and bile acids was not significantly influenced by amounts of total fat ranging from 22% to 40% of daily energy or by differences in polyunsaturated to saturated fatty acids ratio from 0 . 2 to 1 . 7. The only exception was the excretion of bile acids in the second experiment which was 0 . 19 mmol/24 h (75 mg/24 h) higher on the low fat diet than on the moderate fat, high polyunsaturated fat diet (P less than 0 . 01).
研究了不同数量和类型的膳食脂肪对健康志愿者粪便类固醇排泄的影响。在第一个实验中，60名志愿者在为期5周的测试期内，仅比较了四种膳食脂肪类型和数量不同的饮食。在测试期开始前7天和结束时收集粪便，并分别进行分析。在第二个实验中，35名志愿者在13周内，将含22%能量为总脂肪（4%为多不饱和脂肪酸）的低脂饮食与含30%能量为总脂肪（11%为多不饱和脂肪酸）的中脂饮食进行比较。在测试期的前7天以及接近测试期结束时连续7天收集粪便，并按饮食组进行汇总。粪便中性类固醇和胆汁酸的排泄不受每日能量的22%至40%范围内的总脂肪量影响，也不受多不饱和脂肪酸与饱和脂肪酸比例从0.2至1.7变化的影响。唯一的例外是第二个实验中，低脂饮食的胆汁酸排泄量比中脂、高多不饱和脂肪饮食高0.19 mmol/24 h（75 mg/24 h）（P小于0.01）。
