Pogodin M A, Kalacheva E L
Fiziol Zh SSSR Im I M Sechenova. 1983 Apr;69(4):495-500.
In healthy subjects, patterns of inhalation and exhalation durations during growing hypercapnia were studied in free breathing and under the effect of resistive inspiratory resistance 20 and 35 cm H2O/1/sec. Pattern of the inhalation duration was divided into two ranges: the inhalation elongated in the first range and shortened in the second one. The border between these ranges corresponded in free breathing to CO2 tension of exhalation terminal portion (PETCO2)--47.2 +/- 1.0 mm Hg (M +/- m). The 1st range was found in 2/3 of cases in the exhalation duration pattern. Under the effect of additional inspiratory resistance, the border between the two ranges of inhalation pattern shifted towards greater PETCO2 values and was 51.0 +/- 1.0 mm Hg for the greater resistance. The 1st range was found in 1/3 of cases in the exhalation duration dynamics. The shift of the border between the ranges of the inhalation duration pattern occurring in breathing with a resistive load in the course of growing hypercapnia seems to result from an augmentation of cortical effects upon breathing and/or weakening of afferent influences from the lung stretch receptors under these conditions.
在健康受试者中，研究了在自由呼吸以及在20和35 cm H2O/1/秒的吸气阻力作用下，高碳酸血症逐渐加重过程中的吸气和呼气持续时间模式。吸气持续时间模式分为两个范围：在第一个范围内吸气延长，在第二个范围内吸气缩短。在自由呼吸时，这些范围之间的边界对应于呼气末部分的二氧化碳分压（PETCO2）——47.2±1.0 mmHg（平均值±标准差）。在2/3的呼气持续时间模式病例中发现了第一个范围。在额外吸气阻力的作用下，吸气模式的两个范围之间的边界向更高的PETCO2值移动，对于更大的阻力，该边界为51.0±1.0 mmHg。在1/3的呼气持续时间动态变化病例中发现了第一个范围。在高碳酸血症逐渐加重过程中，在有阻力负荷的呼吸中，吸气持续时间模式范围之间的边界移动似乎是由于在这些条件下皮质对呼吸的影响增强和/或肺牵张感受器传入影响减弱所致。
