不同γ干扰素对α和β干扰素耐药的小鼠白血病细胞的作用
Action of different gamma interferons on mouse leukemic cells resistant to alpha and beta interferons.
作者信息
Besançon F, Wietzerbin J, Stefanos S, Wietzerbin J, Falcoff E
出版信息
Infect Immun. 1983 Aug;41(2):822-5. doi: 10.1128/iai.41.2.822-825.1983.
Abstract
Phytohemagglutinin-induced interferon-gamma (IFN-gamma) was reported to act on mouse leukemic L1210 R cells resistant to IFN-alpha and -beta. Results reported here show that these cells are also sensitive to various preparations of murine IFN-gamma derived from different sources and purified to different degrees and that lymphokines present in the preparations are not involved in the antiviral effect of IFN. In addition, IFN-gamma preparation increases concanavalin A binding to L1210 S and L1210 R cells indicating that the sensitivity of L1210 R cells to IFN-gamma is not limited to its antiviral effect.
摘要
据报道，植物血凝素诱导的γ干扰素（IFN-γ）作用于对α干扰素和β干扰素耐药的小鼠白血病L1210 R细胞。此处报道的结果表明，这些细胞对源自不同来源并纯化至不同程度的各种小鼠IFN-γ制剂也敏感，并且制剂中存在的淋巴因子不参与IFN的抗病毒作用。此外，IFN-γ制剂增加了伴刀豆球蛋白A与L1210 S和L1210 R细胞的结合，这表明L1210 R细胞对IFN-γ的敏感性不仅限于其抗病毒作用。
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