Cantell K, Hirvonen S, Pyhälä L, De Reus A, Schellekens H
J Gen Virol. 1983 Aug;64 (Pt 8):1823-6. doi: 10.1099/0022-1317-64-8-1823.
Rabbits and rhesus monkeys were injected with 3 X 10(5) units of human gamma interferon (IFN) prepared in human leukocyte suspensions. Circulating IFN was detected up to 4 h after intravenous administration. Intramuscular injection maintained a relatively stable serum IFN level of about 50 units/ml for 7 to 9 h. The results in both species were similar. Little or no circulating IFN was detected after subcutaneous injection of 3 X 10(5) units, but 1.5 X 10(6) units maintained about 50 units per ml of serum for 30 h. Pharmacokinetically, human gamma IFN resembled human alpha interferons rather than human beta IFN.
给兔子和恒河猴注射了用人白细胞悬液制备的3×10⁵单位人γ干扰素（IFN）。静脉给药后长达4小时可检测到循环中的IFN。肌肉注射可使血清IFN水平在7至9小时内维持在约50单位/毫升的相对稳定状态。两个物种的结果相似。皮下注射3×10⁵单位后几乎检测不到或检测不到循环中的IFN，但1.5×10⁶单位可使血清中每毫升维持约50单位达30小时。从药代动力学角度来看，人γ干扰素类似于人α干扰素而非人β干扰素。
