Cantell K, Pyhälä L
J Infect Dis. 1976 Jun;133 Suppl:A6-12. doi: 10.1093/infdis/133.supplement_2.a6.
Most of the human leukocyte interferon or rabbit serum interferon administered intravenously to rabbits was detectabble in their plasma 1 min after injection. An increase in the dose did not affect the early clearance of human interferon but did prolong its persistence in the serum. Repeated intramuscular injections had no effect on the kinetics of circulating interferon. The purity of the preparation influenced the rate at which interferon entered the blood after intramuscular or subcutaneous injection but did not affect clearance from the blood after intravenous injection. The circulating interferons obtained after intravenous or intramuscular administration cleared at similar rates. During the first 1-2 hr after intravenous or intramuscular injection into rats, the interferon levels were lower in lymph than in serum; after 2 hr lymph and serum samples contained similar amounts of interferon.
给兔子静脉注射的大多数人白细胞干扰素或兔血清干扰素在注射后1分钟可在其血浆中检测到。剂量增加不影响人干扰素的早期清除，但确实延长了其在血清中的持续时间。重复肌肉注射对循环干扰素的动力学没有影响。制剂的纯度影响肌肉或皮下注射后干扰素进入血液的速率，但不影响静脉注射后从血液中的清除。静脉或肌肉给药后获得的循环干扰素以相似的速率清除。在给大鼠静脉或肌肉注射后的最初1-2小时内，淋巴中的干扰素水平低于血清中的；2小时后，淋巴和血清样本中的干扰素含量相似。
