Miyamoto E, Tsuji A, Yamana T
J Pharm Sci. 1983 Jun;72(6):651-4. doi: 10.1002/jps.2600720615.
The effects of various nonionic and ionic surfactants and two bile salts (sodium cholate and sodium taurocholate) on the GI absorption of beta-lactam antibiotics were investigated using the in situ rat GI perfusion technique. Addition of 10 mM polyoxyethylene-23-lauryl ether in the perfusion solution reduced the absorption of propicillin by the stomach and markedly increased the absorption of propicillin and cefazolin by the small intestine. Ester-type nonionic surfactants and bile salts exerted no significant influence on the intestinal absorption of these antibiotics.
使用大鼠原位胃肠道灌注技术，研究了各种非离子和离子表面活性剂以及两种胆盐（胆酸钠和牛磺胆酸钠）对β-内酰胺类抗生素胃肠道吸收的影响。在灌注液中添加10 mM聚氧乙烯-23-月桂醚可降低胃对丙匹西林的吸收，并显著增加小肠对丙匹西林和头孢唑林的吸收。酯型非离子表面活性剂和胆盐对这些抗生素的肠道吸收没有显著影响。
