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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Van Hoogdalem E J, Wackwitz A T, De Boer A G, Cohen A F, Breimer D D

Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.

Br J Clin Pharmacol. 1989 Jan;27(1):75-81. doi: 10.1111/j.1365-2125.1989.tb05337.x.

The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/- s.d.) from 5.0 +/- 1.2% to 9.1 +/- 1.3% and 9.2 +/- 1.5%, respectively. After rectal bolus delivery octanoate increased the mean cefoxitin bioavailability from 7 +/- 3% to 17 +/- 3%, whereas bolus salicylate did not produce a statistically significant effect. All formulations were well tolerated by the volunteers. 3. It is concluded that both octanoate and salicylate are capable of enhancing rectal cefoxitin absorption in man; rate of delivery seems to be an important factor.

在健康志愿者中研究了辛酸钠和水杨酸钠对头孢西丁直肠吸收的影响。药物溶液以推注或零级输注的方式给药。2. 直肠输注时，辛酸钠和水杨酸钠均提高了头孢西丁的平均生物利用度（±标准差），分别从5.0±1.2%提高到9.1±1.3%和9.2±1.5%。直肠推注给药后，辛酸盐使头孢西丁的平均生物利用度从7±3%提高到17±3%，而推注水杨酸盐未产生统计学上的显著影响。所有制剂志愿者均耐受性良好。3. 得出的结论是，辛酸盐和水杨酸盐均能够提高人体直肠中头孢西丁的吸收；给药速率似乎是一个重要因素。

Van Hoogdalem E J, Wackwitz A T, De Boer A G, Cohen A F, Breimer D D

Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.

Br J Clin Pharmacol. 1989 Jan;27(1):75-81. doi: 10.1111/j.1365-2125.1989.tb05337.x.

The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/- s.d.) from 5.0 +/- 1.2% to 9.1 +/- 1.3% and 9.2 +/- 1.5%, respectively. After rectal bolus delivery octanoate increased the mean cefoxitin bioavailability from 7 +/- 3% to 17 +/- 3%, whereas bolus salicylate did not produce a statistically significant effect. All formulations were well tolerated by the volunteers. 3. It is concluded that both octanoate and salicylate are capable of enhancing rectal cefoxitin absorption in man; rate of delivery seems to be an important factor.

在健康志愿者中研究了辛酸钠和水杨酸钠对头孢西丁直肠吸收的影响。药物溶液以推注或零级输注的方式给药。2. 直肠输注时，辛酸钠和水杨酸钠均提高了头孢西丁的平均生物利用度（±标准差），分别从5.0±1.2%提高到9.1±1.3%和9.2±1.5%。直肠推注给药后，辛酸盐使头孢西丁的平均生物利用度从7±3%提高到17±3%，而推注水杨酸盐未产生统计学上的显著影响。所有制剂志愿者均耐受性良好。3. 得出的结论是，辛酸盐和水杨酸盐均能够提高人体直肠中头孢西丁的吸收；给药速率似乎是一个重要因素。