Johnston M G, Feuer C
J Pharmacol Exp Ther. 1983 Aug;226(2):603-7.
Contractions of lymphatic vessels play an important role in regulating lymph flow; however, little is known of the pharmacological properties of these vessels and the mechanisms regulating the contractions. Earlier work had suggested that arachidonic acid metabolites may play some role in the contractile process and in this report we have assessed the effects of various inhibitors of arachidonate metabolism on the contractions of bovine mesenteric lymphatic rings suspended in tissue baths. Aspirin and indomethacin (cyclooxygenase inhibitors), BW 755C (a cyclooxygenase and lipoxygenase inhibitor) and FPL 55712 (a slow reacting substance of anaphylaxis-leukotriene-antagonist) suppressed the phasic contractions of spontaneously active vessels. The addition of arachidonate to noncontracting vessels elicited phasic and tonic contractile activities which were similarly blocked with these drugs, as were the contractions elicited with several agonists. These results suggest that lymphatic vessel contractions are extremely susceptible to suppression with inhibitors of arachidonate metabolism implying that these drugs may alter extravascular fluid dynamics by a direct effect on the lymphatic vessel. The intrinsic contractile regulatory mechanism may involve the production of arachidonate products within the vessel.
淋巴管的收缩在调节淋巴流动中起着重要作用；然而，对于这些血管的药理学特性以及调节收缩的机制却知之甚少。早期的研究表明，花生四烯酸代谢产物可能在收缩过程中发挥一定作用，在本报告中，我们评估了各种花生四烯酸代谢抑制剂对置于组织浴中的牛肠系膜淋巴环收缩的影响。阿司匹林和吲哚美辛（环氧化酶抑制剂）、BW 755C（一种环氧化酶和脂氧化酶抑制剂）以及FPL 55712（一种过敏反应慢反应物质 - 白三烯拮抗剂）抑制了自发活动血管的相性收缩。向无收缩的血管中添加花生四烯酸会引发相性和紧张性收缩活动，这些活动同样会被这些药物阻断，几种激动剂引发的收缩也是如此。这些结果表明，淋巴管收缩极易受到花生四烯酸代谢抑制剂的抑制，这意味着这些药物可能通过对淋巴管的直接作用来改变血管外液动力学。内在的收缩调节机制可能涉及血管内花生四烯酸产物的产生。
