Ciccoli L, Comporti M
Lipids. 1983 May;18(5):363-70. doi: 10.1007/BF02537233.
The changes occurring in the fatty acid composition of the erythrocyte lipids during the first weeks of life were studied in the rat. The major changes consisted of a progressive decrease in oleic acid and a progressive increase in linoleic acid. A lower but significant increase in arachidonic acid was also observed. These changes are not related to variations in erythrocyte age; rather, they appear to be related to the age of the animal. Since somewhat similar changes were observed in the fatty acid composition of the major lipid classes of plasma during the first weeks of life, the possibility that these variations could account for the changes in the fatty acid composition of erythrocyte lipids was considered. Some support to this possibility was found in the results of experiments in which erythrocytes taken from 15-day-old rats were incubated with plasma taken from newborn rats. The changes in the fatty acid composition of erythrocytes and plasma lipids do not appear to be dependent on dietary lipids, since they occur during the suckling period, i.e., before the rats begin to ingest the pelleted diet which presents a fatty acid pattern completely different to that of the dams' milk.
在大鼠中研究了出生后第一周内红细胞脂质脂肪酸组成的变化。主要变化包括油酸逐渐减少和亚油酸逐渐增加。还观察到花生四烯酸有较低但显著的增加。这些变化与红细胞年龄的变化无关；相反，它们似乎与动物的年龄有关。由于在出生后第一周内血浆主要脂质类别的脂肪酸组成中观察到了 somewhat similar 的变化，因此考虑了这些变化可能解释红细胞脂质脂肪酸组成变化的可能性。在将 15 日龄大鼠的红细胞与新生大鼠的血浆一起孵育的实验结果中发现了对这种可能性的一些支持。红细胞和血浆脂质脂肪酸组成的变化似乎不依赖于膳食脂质，因为它们发生在哺乳期，即在大鼠开始摄入颗粒饲料之前，颗粒饲料的脂肪酸模式与母鼠乳汁的脂肪酸模式完全不同。
