Rubin D M, Rubin E J
Med Hypotheses. 1983 Apr;10(4):469-71. doi: 10.1016/0306-9877(83)90014-2.
The sera of patients who suffer from melanoma and mammary carcinoma show higher tyrosinase activity than normal sera. The enzyme tyrosinase oxidizes tyrosine to DOPA and also catalizes the oxidation of DOPA to Melanin. The catalytic oxidation might also occur in tyrosine while it is conjugated to other amino acids in a polypeptide or a protein molecule. It is theorized here that gamma globulins and interferons are vulnerable to this catalytic oxidation which eventually denaturates them and diminishes their immunological properties.
患有黑色素瘤和乳腺癌的患者血清显示出比正常血清更高的酪氨酸酶活性。酪氨酸酶将酪氨酸氧化为二羟基苯丙氨酸（DOPA），并且还催化DOPA氧化为黑色素。当酪氨酸在多肽或蛋白质分子中与其他氨基酸结合时，催化氧化也可能在酪氨酸中发生。本文提出理论，γ球蛋白和干扰素易受这种催化氧化作用的影响，最终使其变性并降低其免疫特性。
