Green D O
J Clin Psychiatry. 1978 May;39(5):481-2.
Tricyclic antidepressant plasma levels have greatly expanded the capabilities of the physician in treating depression. Although still not widely available to the practicing psychiatrist, plasma levels can make an important difference in treating the "drug resistant" depressed patient in particular. The following case report with the use of doxepin underscores the clinical significance of trychclic plasma levels, plus lends support to the previous reports that there is a therapeutic plasma range for the tricyclics which if at too high a level can be as ineffective as too low a level.
三环类抗抑郁药的血浆水平极大地扩展了医生治疗抑郁症的能力。尽管执业精神科医生仍无法广泛获取血浆水平检测，但血浆水平检测对于治疗“耐药性”抑郁症患者尤其重要。以下使用多塞平的病例报告强调了三环类药物血浆水平的临床意义，同时也支持了之前的报告，即三环类药物存在一个治疗性血浆范围，血浆水平过高或过低都可能无效。
