突变分析表明，钙离子诱导的钾电流关闭了草履虫中的一种兴奋类型。
Mutant analysis shows that the Ca2+-induced K+ current shuts off one type of excitation in Paramecium.
作者信息
Saimi Y, Hinrichsen R D, Forte M, Kung C
出版信息
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5112-6. doi: 10.1073/pnas.80.16.5112.
Abstract
Two mutants of Paramecium tetraurelia, called "pantophobiacs," were found to lack most of the slow Ca2+-induced K+ outward current. Passive properties, the transient Ca2+ inward current, and the fast depolarization-induced K+ outward current remain normal. The mutant defect reduces the ability to shut off a normal, excited state of the membrane and results in repeated, long backward swimming instead of the wild-type jerks in response to a variety of ions, to heat, and to touch.
摘要
发现草履虫双小核草履虫的两个突变体“泛恐惧症者”缺乏大部分缓慢的钙诱导钾外向电流。被动特性、短暂的钙内向电流和快速去极化诱导的钾外向电流保持正常。突变体缺陷降低了关闭正常兴奋膜状态的能力，并导致在对各种离子、热和触摸作出反应时，反复进行长时间的向后游动，而不是野生型的急动。
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