Storch W
Z Gesamte Inn Med. 1983 May 1;38(9):35-6.
As virus-associated autoimmune hepatitis a frequently chronic HBsAg-seronegative hepatitis was defined, in which in the liver tissue virus-markers and in the serum high titre (titre more than 1:320) autoantibodies are to be proved. The immunohistological findings of the liver of 11 patients with such a disease suggest a hepatitis B-virus, a hepatitis non-A/non-B-virus and combination forms. The solitary occurrence of virus-markers seems to be typical. In the hepatitis B-associated form furthermore a diffuse IgG-deposition at the liver cell membrane was characteristic as well as focal cytoplasmatic deposits of IgG, IgA, IgM and of C 3. In the hepatitis non-A/non-B-associated form solitarily above all nuclearly a non-A/non-B-associated-antigen, focally nuclearly a non-A/non-B-associated-antigen, focally nuclearly and cytoplasmatically IgE and diffusely cytoplasmatically IgG (with lobule-central accent) was found. The immunohistological findings, particularly the solitary occurrence of virus-markers, might be an expression of a genetically determined, no doubt, increased but incomplete immune attack of the host to the virus-infected liver cells.
由于病毒相关性自身免疫性肝炎常被定义为一种慢性HBsAg血清学阴性肝炎，其中在肝组织中需证实存在病毒标志物，在血清中需证实存在高滴度（滴度大于1:320）自身抗体。11例此类疾病患者肝脏的免疫组织学检查结果提示为乙型肝炎病毒、非甲非乙型肝炎病毒及混合形式。病毒标志物单独出现似乎较为典型。在乙型肝炎相关性形式中，肝细胞膜弥漫性IgG沉积以及IgG、IgA、IgM和C3的局灶性细胞质沉积也具有特征性。在非甲非乙型肝炎相关性形式中，主要单独在细胞核内发现非甲非乙型相关抗原，在细胞核内局灶性发现非甲非乙型相关抗原，在细胞核和细胞质内局灶性发现IgE，在细胞质内弥漫性发现IgG（以小叶中央为主）。免疫组织学检查结果，尤其是病毒标志物的单独出现，可能是宿主对病毒感染肝细胞的遗传决定的、无疑增强但不完全的免疫攻击的一种表现。
