Wolfendale M R, King S, Usherwood M M
Br Med J (Clin Res Ed). 1983 Aug 20;287(6391):526-8. doi: 10.1136/bmj.287.6391.526.
A retrospective study was conducted to examine the pattern of a disturbing increase in abnormal cervical smears in one health district. Past records over fifteen years (1965-79) were analysed to produce pick up rates according to age, screening state, severity of lesion, and area of residence. Main findings included an increased pick up rate in unscreened (5.8 to 12.9/1000 smears) and screened (0.9 to 3.6/1000 smears) women. The order of increase was proportionately much higher in women under 40 years. The only significant epidemiological variable in the catchment area was a substantial population increase, overweighted by the younger age groups. The principal conclusion of the study was that the increased pick up rates of abnormal cervical smears in the district reflected a true increase in the incidence of premalignant lesions of the cervix. Screening efforts aided by computerisation should be examined nationwide in order to reach high risk groups and thus try to prevent an increase in carcinoma of the cervix.
开展了一项回顾性研究,以调查某一健康区宫颈涂片异常令人不安的增加模式。分析了过去十五年(1965 - 1979年)的记录,以得出按年龄、筛查状况、病变严重程度和居住地区划分的检出率。主要发现包括未筛查女性(5.8至12.9/1000涂片)和已筛查女性(0.9至3.6/1000涂片)的检出率均有所增加。40岁以下女性的增加幅度相对更高。集水区唯一显著的流行病学变量是人口大幅增加,且年轻年龄组占比过高。该研究的主要结论是,该地区宫颈涂片异常检出率的增加反映了宫颈癌前病变发病率的真实上升。应在全国范围内检查借助计算机化的筛查工作,以便覆盖高危人群,从而努力预防宫颈癌发病率的上升。