Choie D D, Copley M P, Gindhart T D
Cancer Lett. 1983 Jun;19(2):195-8. doi: 10.1016/0304-3835(83)90154-4.
Cisplatin (cis-dichlorodiammineplatinum-II), an antitumor agent containing platinum, produced acute necrotizing enteritis in rats. This toxic side effect was significantly reduced by oral treatment with CaNa2EDTA. The protective effect of CaNa2EDTA against intestinal cytotoxicity of cisplatin was dose-related. Based on histopathological evaluation of cell necrosis and mitotic index, it was estimated that pretreatment with CaNa2EDTA in drinking water (75 mM) and by gavage (1.5 g/kg) prevented intestinal cytotoxicity by up to 90% compared with cisplatin controls.
顺铂（顺式二氯二氨铂-II）是一种含铂的抗肿瘤药物，可在大鼠中引发急性坏死性肠炎。通过口服CaNa2EDTA治疗，这种毒副作用显著降低。CaNa2EDTA对顺铂肠道细胞毒性的保护作用与剂量相关。基于对细胞坏死和有丝分裂指数的组织病理学评估，据估计，与顺铂对照组相比，饮用水中添加CaNa2EDTA（75 mM）并通过灌胃给予（1.5 g/kg）进行预处理可使肠道细胞毒性降低多达90%。
