Maeta M, Mizusawa K, Koga S
Gastroenterol Jpn. 1987 Jun;22(3):370-3. doi: 10.1007/BF02774263.
Fulminant, necrotizing colitis is a frequent, and generally fatal, complication of severe granulocytopenia, occurring during the treatment of hematological malignancies. In these cases, the patient complains of severe peritonitis, including nausea, vomiting, abdominal pain, diarrhea or melena, and a high temperature. Here, a rare case of anticancer chemotherapy-induced diffuse necrotizing enterocolitis throughout the entire intestinal tract is presented, which developed in a patient who did not have a hematologic malignancy but who had colon cancer, the only clinical symptom of which was watery stools, without any evidence of peritoneal irritation. Full attention should be paid to progressive diarrhea in patients with malignancies during anticancer chemotherapy.
暴发性坏死性结肠炎是严重粒细胞缺乏症常见且通常致命的并发症，发生于血液系统恶性肿瘤治疗期间。在这些病例中，患者主诉严重腹膜炎，包括恶心、呕吐、腹痛、腹泻或黑便，以及高热。本文报告了1例罕见的抗癌化疗引起的全肠道弥漫性坏死性小肠结肠炎，该病例发生在1例没有血液系统恶性肿瘤但患有结肠癌的患者身上，其唯一临床症状是水样便，无任何腹膜刺激征证据。抗癌化疗期间，恶性肿瘤患者出现进行性腹泻时应予以充分关注。
