Mathew L, Gopinathan P M, Purkayastha S S, Sen Gupta J, Nayar H S
Eur J Appl Physiol Occup Physiol. 1983;51(1):137-44. doi: 10.1007/BF00952546.
Studies were carried out to find out the role of chemoreceptor sensitivity in the causation of maladaptation syndromes on acute exposure to altitude. The experiments were done in two phases. In phase I, the responses in chemoreceptor sensitivity were studied in altitude acclimatized subjects and compared with those who suffered from either High Altitude Pulmonary Oedema (HAPO) or Acute Mountain Sickness (AMS). In Phase II, a similar comparison was done in two groups of subjects, one representing normal sojourners at 3,500 m and the other being subjects who had just recovered from HAPO. The first phase was done at Delhi; and the second at an altitude of 3,500 m. Parameters of assessment were hypoxic sensitivity, carbon dioxide sensitivity, ventilation (VE), respiratory frequency (Rf), forced vital capacity (FVC), forced expiratory volume at the first second (FEV1), heart rate (HR), blood pressure (BP), and oral temperature (Tor). The results showed significantly lower sensitivity to both hypoxia and carbon dioxide in maladapted subjects, as compared to those who were acclimatized in both the categories suggesting thereby that reduced chemoreceptor sensitivity might be an initiating factor in the causation of maladaptation syndromes at altitude.
开展了多项研究，以探究化学感受器敏感性在急性暴露于高原时适应不良综合征病因中的作用。实验分两个阶段进行。在第一阶段，研究了高原习服者的化学感受器敏感性反应，并与患有高原肺水肿（HAPO）或急性高原病（AMS）的患者进行了比较。在第二阶段，对两组受试者进行了类似的比较，一组是在3500米处的正常旅居者，另一组是刚从HAPO中康复的受试者。第一阶段在德里进行；第二阶段在海拔3500米处进行。评估参数包括低氧敏感性、二氧化碳敏感性、通气量（VE）、呼吸频率（Rf）、用力肺活量（FVC）、第一秒用力呼气量（FEV1）、心率（HR）、血压（BP）和口腔温度（Tor）。结果显示，与两类习服者相比，适应不良的受试者对低氧和二氧化碳的敏感性显著降低，这表明化学感受器敏感性降低可能是高原适应不良综合征病因中的一个起始因素。
