Sherertz R J, Sarubbi F A
J Clin Microbiol. 1983 Jul;18(1):160-4. doi: 10.1128/jcm.18.1.160-164.1983.
During a 3-year study period in a university teaching hospital, 417 nosocomial infections associated with Pseudomonas aeruginosa were documented in 321 patients. The overall rate of P. aeruginosa nosocomial infection was 5.3 cases per 1,000 patients. Residence on the surgery or medicine service, advanced patient age, and exposure to the burn, surgery, or medicine intensive care units correlated with higher rates of infection. The most common sites for P. aeruginosa infection were the lower respiratory tract, urinary tract, blood stream, and surgical wounds. Nosocomial P. aeruginosa lower respiratory tract and blood stream infections were significantly associated with exposure to certain intensive care units, whereas P. aeruginosa urinary tract infections more commonly occurred on the neurology and neurosurgery services. Results of live antigen serotyping showed that serotype 6 was most common, followed by serotypes 1 and 11. Serotype 6 correlated with resistance to carbenicillin, gentamicin, and tobramycin, and serotype 11 correlated with resistance to carbenicillin. Two-thirds of the isolates tested were sensitive to carbenicillin, gentamicin, and tobramycin, but 13.2% were resistant to all three of these drugs. P. aeruginosa isolates resistant to all three drugs were associated with urinary tract infections.
在一所大学教学医院进行的为期3年的研究期间，321例患者记录了417例与铜绿假单胞菌相关的医院感染。铜绿假单胞菌医院感染的总体发生率为每1000例患者5.3例。入住外科或内科病房、患者年龄较大以及暴露于烧伤、外科或内科重症监护病房与较高的感染率相关。铜绿假单胞菌感染最常见的部位是下呼吸道、泌尿道、血流和手术伤口。医院获得性铜绿假单胞菌下呼吸道和血流感染与暴露于某些重症监护病房显著相关，而铜绿假单胞菌泌尿道感染更常见于神经科和神经外科病房。活菌抗原血清分型结果显示，血清型6最常见，其次是血清型1和11。血清型6与对羧苄西林、庆大霉素和妥布霉素的耐药性相关，血清型11与对羧苄西林的耐药性相关。三分之二的受试分离株对羧苄西林、庆大霉素和妥布霉素敏感，但13.2%对这三种药物均耐药。对所有三种药物耐药的铜绿假单胞菌分离株与泌尿道感染相关。
