Schmeisser D D, Kummerow F A, Baker D H
J Nutr. 1983 Sep;113(9):1777-83. doi: 10.1093/jn/113.9.1777.
Feeding diets with 4% L-lysine to the chick produces an elevation of plasma lipids which does not occur when feeding an excess of any other amino acid. Experiments were conducted to determine whether lysine-induced hyperlipidemia is secondary to the antagonistic effect of lysine on arginine or to the anorexia which accompanies lysine feeding, and in addition, whether the lysine-induced hypercholesterolemia is affected by chick age. In all experiments gain and food intake were reduced by feeding chicks 4% lysine. Plasma cholesterol and triglyceride were elevated, but high-density-lipoprotein cholesterol, as a percentage of total, was reduced. Addition of dietary arginine up to 4% failed to reverse the depression in performance and elevation of plasma lipids. Pair-feeding the control diet to the amount consumed by lysine-fed chicks did not elevate plasma lipids above control levels. Thus, lysine-induced hyperlipidemia is not mediated by the antagonistic effect of lysine on arginine nor by the effect of lysine on food intake. The high-lysine diet prevented the normal decline in plasma cholesterol expected with advancing age of chicks. Preliminary results suggested that excess lysine stimulated cholesterol biosynthesis.
给雏鸡喂食含4% L-赖氨酸的日粮会导致血浆脂质升高，而喂食过量其他任何氨基酸时则不会出现这种情况。进行了实验以确定赖氨酸诱导的高脂血症是继发于赖氨酸对精氨酸的拮抗作用还是继发于赖氨酸喂食时伴随的厌食症，此外，还研究了赖氨酸诱导的高胆固醇血症是否受雏鸡年龄的影响。在所有实验中，给雏鸡喂食4%赖氨酸会使体重增加和采食量减少。血浆胆固醇和甘油三酯升高，但高密度脂蛋白胆固醇占总量的百分比降低。添加高达4%的日粮精氨酸未能扭转生产性能的下降和血浆脂质的升高。将对照日粮按赖氨酸喂养雏鸡的采食量进行配对喂养，并未使血浆脂质升高至对照水平以上。因此，赖氨酸诱导的高脂血症既不是由赖氨酸对精氨酸的拮抗作用介导的，也不是由赖氨酸对采食量的影响介导的。高赖氨酸日粮阻止了雏鸡随着年龄增长血浆胆固醇正常下降的情况。初步结果表明，过量的赖氨酸会刺激胆固醇的生物合成。
