Okia N O
Life Sci. 1983 Sep 26;33(13):1261-8. doi: 10.1016/0024-3205(83)90007-3.
Preincubation of pituitary cells for 48 hours with estrogen or clomiphene citrate did not enhance LH release of dispersed pituitary cells after incubation for 4 hours without the secretagogues. In the presence of GnRH, estrogen increased release, but neither the racemic mixture of clomiphene nor its two trans and cis isomers had any appreciable effect on LH release. It is concluded that contrary to published reports, clomiphene in the rat pituitary may behave differently from estrogen in its effects on gonadotrphin release by dispersed cells.
垂体细胞与雌激素或枸橼酸氯米芬预孵育48小时后，在无促分泌剂的情况下孵育4小时，并未增强分散垂体细胞的促黄体生成素（LH）释放。在促性腺激素释放激素（GnRH）存在的情况下，雌激素可增加释放，但氯米芬的消旋混合物及其两种反式和顺式异构体对LH释放均无明显影响。得出的结论是，与已发表的报告相反，大鼠垂体中的氯米芬对分散细胞促性腺激素释放的影响可能与雌激素不同。
