Ule G, Schwechheimer K, Tschahargane C
Virchows Arch A Pathol Anat Histopathol. 1983;400(3):297-308. doi: 10.1007/BF00612191.
We have correlated the light-microscopic features in the unmyelinated hypothalamus with gonadal atrophy in 15 women of 30-111 years of age and in 7 men between 29 and 82 years. In the postmenstrual cases there is a distinct concordance of gonadal atrophy and the manifestation of nucleolar changes (augmentation, multiplication and vacuolization) in many nerve cells of the arcuate and subventricular nuclei. In younger, still fertile women this nucleolar finding was seen only rarely and sporadically, was limited to the arcuate nucleus and was absent in the subventricular nucleus. We interpret this nucleolar finding as a feedback effect. In man, too, this coincidence is obvious with age and in gonadal atrophy, with fewer nucleolar changes in old age than are seen in women. This difference is probably caused by a more rapid drop of the estradiol than of the testosterone level. - The hypertrophy of the subventricular nucleus (Sheehan and Kovacs) was also observed in our postmenstrual cases.
我们将15名年龄在30至111岁之间的女性和7名年龄在29至82岁之间的男性下丘脑无髓鞘区域的光学显微镜特征与性腺萎缩进行了关联研究。在绝经后的病例中，性腺萎缩与弓状核和室旁核许多神经细胞核仁变化（增大、增多和空泡化）的表现明显一致。在较年轻、仍有生育能力的女性中，这种核仁变化仅偶尔零星出现，仅限于弓状核，室旁核未见。我们将这种核仁变化解释为一种反馈效应。在男性中，随着年龄增长和性腺萎缩，这种相关性也很明显，老年男性的核仁变化比女性少。这种差异可能是由于雌二醇水平比睾酮水平下降得更快所致。——在我们的绝经后病例中还观察到了室旁核肥大（希恩和科瓦奇）。
