Kaba H, Saito H, Otsuka K, Seto K, Kawakami M
Brain Res. 1983 Sep 5;274(1):156-9. doi: 10.1016/0006-8993(83)90532-2.
Estradiol benzoate administered to ovariectomized female rats significantly elevated the mean spontaneous firing rate and frequency of successful antidromic propagation into the somatodendritic spike and significantly reduced the strength of post-stimulus inhibition in presumed A1 noradrenergic neurons projecting directly to the preoptic and anterior hypothalamic area. The occurrence of both antidromic spikes and post-stimulus inhibition of the majority of these neurons was completely abolished by the injection of 6-hydroxydopamine but not by 5, 7-dihydroxytryptamine directly into the medial forebrain bundle.
给去卵巢雌性大鼠注射苯甲酸雌二醇，可显著提高假定直接投射到视前区和下丘脑前部的A1去甲肾上腺素能神经元的平均自发放电率和向树突棘成功进行逆向传播的频率，并显著降低刺激后抑制的强度。向内侧前脑束直接注射6-羟基多巴胺可完全消除这些神经元中大多数的逆向峰电位和刺激后抑制现象，但注射5,7-二羟基色胺则无此效果。
