淋巴瘤和白血病中κ和λ免疫球蛋白表达与2号和22号染色体异常相关。

Kappa and lambda immunoglobulin expression associated with abnormalities of chromosomes #2 and #22 in lymphoma and leukemia.

作者信息

Sadamori N, Takeuchi J, Abe R, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1983 Oct;10(2):209-12. doi: 10.1016/0165-4608(83)90127-9.

Abstract

The types of surface immunoglobulins on Burkitt lymphoma (BL) cells correlate with the specific chromosomes that are altered in the tumor. For example, BL with a t(2;8) translocation expresses kappa (kappa) light chains, whereas BL with a t(8;22) translocation expresses lambda (lambda) light immunoglobulin chains; these correspond with the locations of the kappa chain genes on chromosome #2 and the lambda chain genes on chromosome #22, respectively (1-5). In order to explain this close correlation between specific translocations and light chain expression in BL and BL-type acute lymphocytic leukemia (ALL) (L3 type), Hecht et al. [6] proposed the concept of position effect, which is reviewed herein.

摘要

伯基特淋巴瘤（BL）细胞表面免疫球蛋白的类型与肿瘤中发生改变的特定染色体相关。例如，发生t(2;8)易位的BL表达κ（kappa）轻链，而发生t(8;22)易位的BL表达λ（lambda）轻免疫球蛋白链；这些分别与2号染色体上κ链基因和22号染色体上λ链基因的位置相对应（1 - 5）。为了解释BL和BL型急性淋巴细胞白血病（ALL，L3型）中特定易位与轻链表达之间的这种密切相关性，赫克特等人[6]提出了位置效应的概念，本文对此进行综述。