佛波酯刺激的牛淋巴细胞中花生四烯酸两种独特代谢物的证明。
Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes.
作者信息
Wrighton S A, Pai J K, Mueller G C
出版信息
Carcinogenesis. 1983 Oct;4(10):1247-51. doi: 10.1093/carcin/4.10.1247.
PMID:6413084
Abstract
Treatment of bovine lymphocytes with phorbol esters activates an oxygen-dependent system for the formation of a class of arachidonic acid metabolites which appears distinct from prostaglandins, prostacyclins, thromboxanes and leukotrienes. A full activation of the system is achieved within minutes by 10(-7) M 12-O-tetradecanoylphorbol-13-acetate. This activation can be largely prevented by the lipoxygenase inhibitors, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid.
摘要
用佛波酯处理牛淋巴细胞可激活一个氧依赖系统，用于形成一类花生四烯酸代谢产物，这类代谢产物似乎不同于前列腺素、前列环素、血栓素和白三烯。10(-7)M 12-O-十四烷酰佛波醇-13-乙酸酯在数分钟内可使该系统完全激活。脂氧合酶抑制剂5,8,11,14-二十碳四炔酸和去甲二氢愈创木酸可在很大程度上阻止这种激活。
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