Brenner S, Dorfman B, Krakowski A, Hazaz B, Yaron M, Michaeli D
Cutis. 1983 Aug;32(2):175-8.
A 27-year-old woman presented with skin lesions and arthritis of the right knee of two days' duration. Her medical history was noncontributory and synovial fluid aspirated from the affected knee and a biopsy of a skin lesion were negative for gonococci. However, after methylene blue staining of cervical and urethral smears, intracellular and extracellular diplococci were demonstrated. Immunofluorescence showed deposits of immunoglobulin complexes of the skin section within the wall of blood vessels and dermal-epidermal junction. Treatment with ampicillin, 4 gm a day, resulted in resolution of the lesions and arthritis in two days. The need for cervical and urethral smears and for better, as yet unavailable tools for the diagnosis of the arthritis dermatitis syndrome, is emphasized.
一名27岁女性因出现持续两天的皮肤病变和右膝关节炎前来就诊。她的病史无特殊提示，从患膝抽取的滑液及皮肤病变活检未发现淋球菌。然而，对宫颈和尿道涂片进行亚甲蓝染色后，发现了细胞内和细胞外双球菌。免疫荧光显示皮肤切片的免疫球蛋白复合物沉积于血管壁和真皮-表皮交界处。每日4克氨苄西林治疗两天后，病变和关节炎症状消退。强调了宫颈和尿道涂片以及目前尚未获得的更好的关节炎性皮炎综合征诊断工具的必要性。
