Richter G C, Levine G M, Shiau Y F
Gastroenterology. 1983 Nov;85(5):1105-12.
These studies were designed to better understand the effects of luminal nutrition on intestinal mass and function. Parenterally nourished rats received a midjejunal infusion of either 0.9% saline, 10% glucose, 10% 3-O-methyl glucose, or 30% glucose. A fifth group underwent sham operation. After 7 days, intestinal mass and in vitro glucose and leucine uptake were measured in the intestine just distal to the infusion site. Luminal infusion led to greater intestinal mass in all groups compared to controls, but only the 10% and 30% glucose groups had significantly greater overall glucose uptake. Kinetic analysis revealed a greater apparent maximal transport rate in both glucose groups. The 30% glucose group had a greater apparent maximal transport rate for leucine and permeability for glucose and leucine. These data confirmed that "work load," in addition to luminal nutrition, maintains intestinal mass. However, adaptation of intestinal transport is more specific and appears to be regulated both by substrate metabolism and caloric density.
这些研究旨在更好地了解肠内营养对肠道质量和功能的影响。接受肠外营养的大鼠在空肠中部输注0.9%生理盐水、10%葡萄糖、10% 3 - O - 甲基葡萄糖或30%葡萄糖。第五组进行假手术。7天后，在输注部位远端的肠段测量肠道质量以及体外葡萄糖和亮氨酸摄取量。与对照组相比，肠内输注使所有组的肠道质量增加，但只有10%和30%葡萄糖组的总体葡萄糖摄取量显著更高。动力学分析显示，两个葡萄糖组的表观最大转运速率更高。30%葡萄糖组的亮氨酸表观最大转运速率以及葡萄糖和亮氨酸的通透性更高。这些数据证实，除肠内营养外，“工作负荷”可维持肠道质量。然而，肠道转运的适应性更具特异性，似乎受底物代谢和热量密度的调节。
