Yoshikawa T, Furukawa Y, Murakami M, Takemura S, Kondo M
Haemostasis. 1983;13(4):262-7. doi: 10.1159/000214758.
Experimental disseminated intravascular coagulation (DIC) can be induced by 4 h sustained infusion of endotoxin at a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of gabexate mesilate (GM) against DIC. Before the infusion of endotoxin, 10(-6), 10(-3), 1, 10, 50 or 100 mg/kg of GM was injected intraperitoneally. The preventive effects against DIC were noted in all the parameters, such as fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count, and the number of renal glomeruli with fibrin thrombi, in rats treated with 1, 10 or 50 mg/kg of GM. From these results it was shown that GM inhibited the aggravation of endotoxin-induced experimental DIC in rats.
实验性弥散性血管内凝血（DIC）可通过以100mg/kg的剂量对大鼠持续输注4小时内毒素来诱发。大鼠DIC实验模型用于研究甲磺酸加贝酯（GM）对DIC的预防作用。在内毒素输注前，腹腔注射10⁻⁶、10⁻³、1、10、50或100mg/kg的GM。在接受1、10或50mg/kg GM治疗的大鼠中，在所有参数上均观察到对DIC的预防作用，这些参数包括纤维蛋白原和纤维蛋白降解产物、纤维蛋白原水平、凝血酶原时间、部分凝血活酶时间、血小板计数以及有纤维蛋白血栓的肾小球数量。从这些结果表明，GM抑制了内毒素诱导的大鼠实验性DIC的加重。
