Yoshikawa T, Murakami M, Furukawa Y, Takemura S, Kondo M
Thromb Res. 1983 Mar 15;29(6):619-25. doi: 10.1016/0049-3848(83)90216-5.
Experimental disseminated intravascular coagulation (DIC) can be induced by 4-h sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of dipyridamole against DIC. Before the infusion of endotoxin, 0.5, 5.0 or 50.0 mg/kg of dipyridamole was injected intraperitoneally. The preventive effect against DIC was noted in all the parameters, such as fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count, and the number of renal glomeruli with fibrin thrombi, in rats treated with 5.0 or 50.0 mg/kg of dipyridamole. From these results, it was shown that dipyridamole inhibited the aggravation of endotoxin-induced experimental DIC in rats.
实验性弥散性血管内凝血（DIC）可通过给大鼠持续4小时输注剂量为100毫克/千克的内毒素来诱发。采用大鼠DIC实验模型研究双嘧达莫对DIC的预防作用。在内毒素输注前，腹腔注射0.5、5.0或50.0毫克/千克的双嘧达莫。在接受5.0或50.0毫克/千克双嘧达莫治疗的大鼠中，在所有参数上均观察到对DIC的预防作用，这些参数包括纤维蛋白原和纤维蛋白降解产物、纤维蛋白原水平、凝血酶原时间、部分凝血活酶时间、血小板计数以及有纤维蛋白血栓的肾小球数量。从这些结果可以看出，双嘧达莫抑制了内毒素诱导的大鼠实验性DIC的加重。
