Binz H, Fenner M, Engel R, Wigzell H
Int J Cancer. 1983 Oct 15;32(4):491-500. doi: 10.1002/ijc.2910320417.
In the present article we describe studies on a chemically induced sarcoma in DA rats. This tumor expresses a unique antigen which can be demonstrated by both syngeneic antibodies and cytotoxic T cells. We have established cytotoxic T-cell lines (CTLs) specific for the tumor and with high efficient killing capacity in vitro. When testing for the ability of such CTLs to inhibit tumor out-growth in vivo, we found that they had to be inoculated together with the tumor and in the presence of T-cell growth factor to provide any significant degree of protection. We thus believe not only that there is a requirement for addition of CTL-stimulating lymphokines in vivo, but also that the CTLs fail to move from one site in vivo to attack relevant tumor cells at another site. No evidence was obtained that the CTLs gradually could acquire such migratory ability in vivo.
在本文中，我们描述了对DA大鼠化学诱导肉瘤的研究。这种肿瘤表达一种独特的抗原，同种抗体和细胞毒性T细胞均可证明这一点。我们已经建立了对该肿瘤具有特异性且在体外具有高效杀伤能力的细胞毒性T细胞系（CTL）。在测试此类CTL体内抑制肿瘤生长的能力时，我们发现必须将它们与肿瘤一起接种，并在T细胞生长因子存在的情况下，才能提供任何显著程度的保护。因此，我们认为不仅体内需要添加刺激CTL的淋巴因子，而且CTL无法从体内一个部位移动到另一部位攻击相关肿瘤细胞。没有证据表明CTL在体内能逐渐获得这种迁移能力。
