一名患有终身性出血性疾病的患者，其血小板对钙离子载体A23187的聚集功能存在缺陷。
Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.
作者信息
Machin S J, Keenan J P, McVerry B A
出版信息
J Clin Pathol. 1983 Oct;36(10):1140-4. doi: 10.1136/jcp.36.10.1140.
Abstract
A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.
摘要
一名患有终身性出血性疾病的患者出现出血时间延长，对花生四烯酸、血栓素A2、血小板活化因子-乙醚和二价钙离子载体A23187的聚集和分泌反应异常。血小板α颗粒和致密颗粒的含量及形态看起来正常。推测的缺陷是由于血小板细胞内钙依赖性过程异常所致。
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