Amidon G L, Lee M, Lee H
J Pharm Sci. 1983 Aug;72(8):943-4. doi: 10.1002/jps.2600720826.
The intestinal absorption of L-lysine-p-nitroanilide, L-alanine-p-nitroanilide, and glycine-p-nitroanilide was studied in perfused rat intestine in the presence of a variety of potential competitive inhibitors. The results indicate that the hydrolysis site(s) show side-chain specificity, and that inhibitors require a free amino group in the alpha-position and must be in the L-configuration to be effective. Glycyl-L-proline, a peptide transport inhibitor, had no effect on the absorption rate.
在存在多种潜在竞争性抑制剂的情况下，对灌注大鼠肠道中L-赖氨酸对硝基苯胺、L-丙氨酸对硝基苯胺和甘氨酸对硝基苯胺的肠道吸收进行了研究。结果表明，水解位点具有侧链特异性，并且抑制剂在α位需要一个游离氨基，且必须为L构型才有效。肽转运抑制剂甘氨酰-L-脯氨酸对吸收速率没有影响。
