Suyama Y, Seki S, Tanaka Y, Tada M, Fujii H, Miyoshi M, Nishimura S, Nishitani T, Katake K
Gan No Rinsho. 1983 Aug;29(9):962-5.
Twenty liver cancer patients, including 9 hepatocellular carcinoma and 11 with metastatic liver cancer, were treated by intra-arteral one-shot chemotherapy. Alterations in blood coagulation and fibrinolysis were observed serially after one-shot chemotherapy by testing the levels of PT, APTT, FDP, fibrinogen, AT III, alpha 2-macroglobulin, and plasminogen. APTT was prolonged, FDP increased, Fbg increased after a transicent decrease, and AT III, alpha 2-M, and plasminogen decreased. The peaks of these alterations occurred within 7 days after the one-shot treatment; recovery was observed after about weeks. The more advanced the cancer, the greater were the alterations.
20例肝癌患者，包括9例肝细胞癌和11例转移性肝癌患者，接受了动脉内一次性化疗。通过检测PT、APTT、FDP、纤维蛋白原、抗凝血酶III、α2-巨球蛋白和纤溶酶原水平，在一次性化疗后连续观察凝血和纤溶的变化。APTT延长，FDP升高，纤维蛋白原短暂下降后升高，抗凝血酶III、α2-M和纤溶酶原下降。这些变化的峰值出现在一次性治疗后的7天内；约数周后观察到恢复。癌症越晚期，变化越大。
