Tamura M, Itakura K, Sayama T, Murakami T, Suzuki Y
Jpn J Med. 1983 Aug;22(3):190-4. doi: 10.2169/internalmedicine1962.22.190.
A comparative study was made of ventilatory and airway occlusion pressure (P0.1; a parameter reflecting respiratory center output) responses to carbon dioxide between 11 patients with bronchial asthma and 10 chronic obstructive lung disease (COLD). Increments in ventilatory volume (VE) produced by a rise in end-tidal CO2 pressure (PETCO2), i.e. delta VE/BSA/delta PETCO2, were smaller in 4 patients with hypercapnic COLD than in 6 normal subjects. On the other hand, increments in P0.1 produced by an elevation of PETCO2 (i.e. delta P0.1/delta PETCO2) tended to be diminished in patients with hypercapnic COLD. Higher values for both VE/BSA and P0.1 were observed in 6 patients with normocapnic COLD, but the differences from corresponding control values failed to achieve statistical significance due to a large variance. In 11 patients with bronchial asthma without attack, VE/BSA elevated significantly at PETCO2 levels of 50 and 60 torr, but values of delta VE/BSA/delta PETCO2 were virtually same as those in normal subjects.
对11例支气管哮喘患者和10例慢性阻塞性肺疾病（COLD）患者的通气和气道阻塞压（P0.1，反映呼吸中枢输出的参数）对二氧化碳的反应进行了比较研究。终末潮气二氧化碳分压（PETCO2）升高所产生的通气量（VE）增量，即δVE/BSA/δPETCO2，在4例高碳酸血症型COLD患者中比在6例正常受试者中更小。另一方面，PETCO2升高所产生的P0.1增量（即δP0.1/δPETCO2）在高碳酸血症型COLD患者中往往减小。6例正常碳酸血症型COLD患者的VE/BSA和P0.1值较高，但由于方差较大，与相应对照值的差异未达到统计学显著性。在11例无发作的支气管哮喘患者中，PETCO2水平为50和60托时，VE/BSA显著升高，但δVE/BSA/δPETCO2值与正常受试者基本相同。
