Rockwell S
J Natl Cancer Inst. 1983 Oct;71(4):765-71.
The effects of mitomycin C alone and in combination with radiation on the cells of EMT6 mouse mammary tumors in BALB/cKaRw mice were examined. At doses near the toxic level, approximately 98% of the tumor cells were killed by a single injection of mitomycin C. Both proliferating and quiescent cells and both hypoxic and aerobic cells were killed by the drug. Cytotoxicity with mitomycin C occurred rapidly and was apparently complete within 30 minutes after injection of the drug . No evidence was found for repair of potentially lethal mitomycin C damage or sublethal mitomycin C damage by the tumor cells. Mitomycin C and radiation in combination produced an additive cytotoxicity; neither agent was found to alter significantly the shape of the dose-response curve for the other agent. The cytotoxicity of mitomycin C and radiation in combination depended on the sequence and timing of the treatments; additive toxicities were obtained when mitomycin C was given just after, just before, or up to 24 hours before irradiation, but the combination was less effective when mitomycin C was given 2-12 hours after irradiation.
研究了丝裂霉素C单独及联合辐射对BALB/cKaRw小鼠EMT6小鼠乳腺肿瘤细胞的影响。在接近毒性水平的剂量下，单次注射丝裂霉素C可杀死约98%的肿瘤细胞。增殖细胞和静止细胞、缺氧细胞和好氧细胞均被该药物杀死。丝裂霉素C的细胞毒性迅速发生，在注射药物后30分钟内显然完全发挥作用。未发现肿瘤细胞对潜在致死性丝裂霉素C损伤或亚致死性丝裂霉素C损伤进行修复的证据。丝裂霉素C与辐射联合产生相加性细胞毒性；未发现一种药物能显著改变另一种药物的剂量反应曲线形状。丝裂霉素C与辐射联合的细胞毒性取决于治疗的顺序和时间；当丝裂霉素C在照射后、照射前或照射前24小时内给药时，可获得相加毒性，但当丝裂霉素C在照射后2至12小时给药时，联合治疗效果较差。
