Elin R J, Alling D W
J Lab Clin Med. 1978 Apr;91(4):666-72.
Magnesium deficiency in rats causes anemia, the mechanism of which is unknown. The effect of dietary magnesium, splenectomy, and magnesium content of erythrocytes on erythrocyte survival was studied in Fisher rats. Half of the animals were splenectomized, the remainder sham-splenectomized; each group was subdivided, and some were placed on a magnesium-deficient diet, the rest on a control diet. After 6 weeks, each of the four subgroups was divided, half were given 51Cr-labeled red cells from magnesium-deficient rats, the remainder, labeled normal red cells. The survival functions of the labeled erythrocytes were fitted to a mathematical model composed of both first-order and accelerating components. The results show that the most important factor influencing erythrocyte survival was dietary magnesium intake. The magnesium content of the transfused red cells affected erythrocyte survival only in the rats fed the control diet, whereas splenectomy affected erythrocyte survival only in rats receiving the magnesium-deficient diet. The accelerating component of the survival function was increased eightfold in the animals fed the magnesium-deficient diet, whereas much smaller changes occurred in the first-order components.
大鼠镁缺乏会导致贫血，但其机制尚不清楚。在费希尔大鼠中研究了饮食镁、脾切除术和红细胞镁含量对红细胞存活的影响。一半动物进行了脾切除，其余动物进行假脾切除；每组再细分，一些动物置于缺镁饮食中，其余动物置于对照饮食中。6周后，四个亚组中的每一组再分开，一半给予来自缺镁大鼠的51Cr标记红细胞，其余给予标记的正常红细胞。将标记红细胞的存活函数拟合为一个由一级和加速成分组成的数学模型。结果表明，影响红细胞存活的最重要因素是饮食镁摄入量。输注红细胞的镁含量仅在喂食对照饮食的大鼠中影响红细胞存活，而脾切除术仅在接受缺镁饮食的大鼠中影响红细胞存活。在喂食缺镁饮食的动物中，存活函数的加速成分增加了八倍，而一级成分的变化则小得多。
